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Postdoctoral Researcher in Integrative Evolutionary Cell Biology (ERC Project IntEvoCell) University of Helsinki – Helsinki Institute of Life Science (HiLIFE) / Faculty of Biological and
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The McWilliams Lab investigates physiological autophagy, a membrane-driven lysosomal degradation pathway essential for cell, circuit and tissue homeostasis. Impairments in autophagy and lysosomal
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, Biochemists and Bioinformaticians working together to understand the molecular mechanisms which regulate immune cell signaling and programming in vivo. We are especially interested in programming of dendritic
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at the site of inflammation. Recent studies have revealed important crosstalk between lymphatic endothelium and immune cells, resulting in phenotypic changes that control immune cell trafficking, fate and
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mechanisms and intercellular dynamics underlying bidirectional cell production by vascular cambium stem cells. We are utilizing lineage tracing techniques, molecular genetics, proteomics, advanced microscopy
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theoretical evolutionary biology, including optimal control theory, life history modelling, adaptive dynamics, and population genetics. This position is part of the interdisciplinary consortium
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-of-the-art approaches in cell biology, imaging, and in-cell structural biology to reveal nanoscale membrane architectures that drive lipid flux in their native context. The group operates across two
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quantitative predictions testable against empirical data from diverse ecological contexts. We use methods from theoretical evolutionary biology, including optimal control theory, life history modelling, adaptive
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organelle biogenesis in metabolic health and disease. We use state-of-the-art approaches in cell biology, imaging, and in-cell structural biology to reveal nanoscale membrane architectures that drive lipid
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vivo electrophysiological techniques (field recordings and whole-cell patch-clamp in vitro; multi-unit activity in vivo), immunocytochemistry, small animal surgery (brain microinjections), behavioural