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elucidation of membrane protein complexes and integrates fundamental cell biology and structural biology by cryo- electron microscopy. The lab has a strong track record in investigating scramblases and their
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metabolism. You will: Quantify nucleolar material state using Digital Holographic Microscopy (DHM) in cancer cell panels ± chemotherapeutics (e.g., CX-5461, oxaliplatin) and in engineered optogenetic models
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early developmental success. You will establish an integrated workflow that combines cryo-electron tomography (cryo-ET), sub-tomogram averaging and expansion microscopy to map/model key sperm structures
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-resolution confocal microscopy, and high-throughput sequencing technologies. The candidate will have the opportunity to have an attractive 1-year post-doc grant with the possibility of 3 additional years. How
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), (cryo-)electron microscopy analysis, and advanced cellular assays utilizing Crispr/Cas9 tagging. . Our mission is to translate these mechanistic discoveries into a detailed understanding of the autophagy
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of biological processes using diverse experimental systems. We apply state-of-the-art technologies, including high-resolution fluorescence microscopy, quantitative proteomics (HDX and XL MS), (cryo-)electron
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, protein biochemistry, electron and fluorescence microscopy and CRISPR/Cas9 genome editing to study the role of the early autophagy machinery in targeting and degrading protein aggregates and organelles
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or electromechanical presses, and sintering experiments will be performed, with specific attention to accurate temperature and gas atmosphere control. Solid-state characterization will involve optical and electron
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interest in cytology, microscopy, and molecular biology. Genuine interest in and commitment to advancing scientific knowledge and innovation. Willing to travel to collaborating partners in Tanzania (IITA
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, and performance. The work combines controlled laboratory experiments with comprehensive analytical approaches to address a key research gap: achieving a mechanistic understanding of how electron donor