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:this project pioneers a new paradigm of General Genome Interpretation (GenGI) models by combining DNA Large Language Models (DLLMs) with Deep Neural Networks to predict human phenotypes directly from Whole Exome
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the modularity and the high degree of addressability of self-assembled DNA nanostructures as a biosynthetic tool to probe fundamental aspects of biology. The recruited postdoc will develop two main projects: (1
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to elucidate the role of histone S-glutathionylation in the regulation of DNA compaction. The cysteine residue of histone H3 has been shown to be S-glutathionylated both in vitro and in vivo (García-Giménez et
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, the primary unit of chromatin, using classical all-atom molecular dynamics simulations. The nucleosome is composed of a double-stranded DNA fragment wrapped around a protein core consisting of eight histones
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The postdoc will realize an EPR analysis on DNA-based enzymes, using 1D and 2D techniques. Two main systems will be investigated, having Copper(II) and Manganese(II) as metal co-factor. Structural and
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origins (bacterial, biological fluids, hybrid nanovectors, etc.). He/she will develop protocols for fluorescent labeling (e.g. DNA paint...), immunolabeling, immunoimmobilization, acquisition, processing
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and protein complexes, pull down - Omics data analysis (RNAseq, ChIPseq, genomic DNA-seq, etc.) - Presenting results in writing and orally - Ensuring the traceability and reliability of results
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substrates using DNA PAINT experiments to analyze the distances between these proteins on a nanometer scale in intact cells. This should reflect the probability of the enzyme to cleave a given protein in the
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: -Culture and maintenance of Symbiodiniaceae strains - Analysis of cell viability and growth - Development of different culture media - Development of transfection/genome editing protocols - DNA and RNA