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. Our mission is to move beyond descriptive biology and develop predictive, mechanistic models that connect molecular regulation to cellular and systems-level phenotypes. The Laboratory of Computational
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the development of genetic autoinflammatory diseases. Using techniques in cell biology, molecular biology and biophysics you will investigate how loss of function of the RNA editing enzyme ADAR1 causes the human
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data. We have developed in vivo single-cell CRISPR technologies to screen for dozens of molecular factors in vivo during developmental and disease. These technologies are a game-changer in the speed
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that regulate plant development and physiology, including adaptation to environmental stresses. They are synthesized in the cell interior and exported across the plasma membrane to bind receptors at the cell
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and Saeys teams. In this research project you will develop and apply algorithms to link clinical phenotypes of metastasis to molecular phenotypes in mouse models. It is known that metastases exhibit
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early developmental success. You will establish an integrated workflow that combines cryo-electron tomography (cryo-ET), sub-tomogram averaging and expansion microscopy to map/model key sperm structures
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-specific synaptic developmental timing to early cortical circuit function and plasticity in ASD” This PhD project focuses on understanding how altered synaptic development—particularly due to SYNGAP1
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facilities and training in advanced techniques. Opportunities for career development, networking, and mentorship. Support for presenting at international conferences and publishing in peer-reviewed
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to neurodegenerative diseases of the central and peripheral nervous system, with an emphasis on understanding the genetic etiology and developing diagnostics and treatment methods for these diseases. Approaches range