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Boudny, Ph.D. Topic title: Lymphoid microenvironment models and their use to study targeted therapy and resistance in B cell malignancies Annotation: Chronic lymphocytic leukemia (CLL) cells and indolent
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pluripotent stem cells. These models represent the current gold standard for replicating organ-level physiology in vitro, offering unprecedented opportunities to study molecular events within realistic tissue
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: Computational biophysics, drug delivery, protein design Keywords:Computer simulations, coarse-grained model, molecular dynamics, membrane fusion, fusion protein, protein design Funding of the PhD candidate: ERC
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: 10.1038/s41467-023-39181-2 Research area: Computational biophysics, drug delivery, protein design Keywords:Computer simulations, coarse-grained model, molecular dynamics, membrane fusion, fusion protein
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microenvironmental interactions of CLL. We will decipher the molecular functions of these lncRNAs using biochemical and cellular approaches and via a novel lncRNA knock-out mouse model. We have engineered mice
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depend on signals in the immune microenvironment. However, the factors that regulate this are mostly unclear. The lab established several models for in vitro and in vivo studies of microenvironmental
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testing targeted therapy options, e.g. using specific inhibitors of TFs or chromatin modification regulators that are currently available or in development. We have identified several TFs that might act as
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biological function in environmental responses using the model plant Arabidopsis thaliana. Building on recent evidence that VEL proteins can form higher-order assemblies through polymerization, a key focus of