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process, but they are not detectable by X-ray crystallography. Therefore we have turned to neutron crystallography to locate the hydrogens (Kelpsas et al. 2021, https://doi.org/10.1107/S2052252521004619
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/s41467-019-08609-z/ ), and in understanding the pathway that link the functional and pathological forms of the protein. Techniques involved will include X-ray and neutron crystallography, small-angle
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fluorescence microscopy and X-ray crystallography. The experimental and theoretical methods used often have their origins in physics. Significant work is devoted to protein self-assembly and co-assembly and
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