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state including CRY1/2, PER, CK1 kinase and other proteins, and a late repressed state where only CRY1 remains associated with CLOCK/BMAL1. Additionally, cytosolic CRY/PER/CK1 containing complexes
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biological methods or proteomics. The PhD project is part of the EU-funded doctoral training network “NEUROMECH”, which seeks to characterize the role of mechanobiology in the pathogenesis of neurodegenerative
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agents, yet how cells detect, repair, and signal this damage remains poorly understood. This project will focus specifically on RNA–protein crosslinks—complex lesions that can disrupt gene expression and
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