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on the structure–function relationship of the bacterial chromosome. How bacteria organize their DNA and how this structure influences gene expression remain open questions. For example: How is the chromosome
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to understand the classic and elusive chromosomal species known as double minutes. Double minutes are extrachromosomal acentric chromatin bodies that are the hallmark of oncogenes in human cancers. Double minutes
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), chromosome conformation capture, and protein interaction studies to discover the basis of cell specific gene expression in leaves. We are looking for a highly motivated postdoctoral scientist who is
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of mammals inhabiting extreme terrestrial biomes. Planned projects combine state-of-the art sequencing methods to generate chromosome-level haplotype-resolved genomes and re-sequencing methods to address
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technicolor. From deciphering the choreography of transcription complexes, chromosomes, and RNA molecules within cells to developing novel approaches to 3D molecular structure determination to understanding how
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chromatin misregulation to replication dynamics, this project aims to uncover mechanisms that enable malignant cells to proliferate while preserving chromosomal integrity. Candidate Profile We seek candidates
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biologist studying genome instability in cancers. Currently, the Tang lab is interested in the molecular mechanisms of chromosome segregation defects (aneuploidy), chromothripsis, transcription replication
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misregulation to replication dynamics, this project aims to uncover mechanisms that enable malignant cells to proliferate while preserving chromosomal integrity. Candidate Profile We seek candidates with a strong
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. Candidates with an interest in the comparative analysis of telomere-to-telomere genomes, non-canonical DNA (i.e., non-B DNA), and sex chromosomes are particularly encouraged to apply. The successful candidate
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play a role in delineating the evolutionary strategy of cells, and preliminary data using chromosome conformation capture techniques are consistent with this idea. This project will first focus on