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Max Planck Institute of Biophysics, Frankfurt am Main | Frankfurt am Main, Hessen | Germany | 2 months ago
and guests from more than 35 countries. It is located at the Campus Riedberg in Frankfurt am Main. The research group of “Structure and Dynamics of Chromosomes” led by Eugene Kim at the Max Planck
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work package, as a Postdoctoral researcher in evolutionary genomics of sex chromosomes and sex-specific recombination in anurans andfor the validation of your doctoral research and, contains: A
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alterations in iPS cells. This project focuses on 8p syndrome, a developmental disorder caused by a complex rearrangement on chromosome 8p that results in neurodevelopmental delays, epilepsy, and other clinical
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chromosome 8p that results in neurodevelopmental delays, epilepsy, and other clinical features. Using our recently developed chromosome engineering approach, we have created isogenic stem cell lines that allow
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of gene dosage in regulating cellular function in male and female animals - from individual genes to chromosome-wide scales. We combine work in non-model organisms (like mosquitos or brine shrimp) with
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that polyploidization disrupts dosage compensation in species with sex chromosomes. If verified, this theory could explain the rarity of polyploids in animals compared to plants. We will use Silene latifolia, a dioecious
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of extra-chromosomal DNA in human cancers. The position is funded for initially two years (with options of extension) by the CRUK and NCI Cancer Grand Challenge to work on the evolutionary theory and
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Postdoctoral position to study Polo kinase and centrosome abnormalities in cancer and other diseases
centriole duplication, bipolar spindle formation, chromosome segregation, cell division, and proliferation. Dysregulation of Plk4/Plk1-dependent processes, by mutations in their associated cellular components
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that enable structural determination of native chromatin-associated complexes, we aim to elucidate the structural foundations of key biological events on eukaryotic chromosomes. The Arimura Lab provides a
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biology techniques including PCR and cell culture will be essential. Experience of Next Generation Sequencing based protocols including ATAC-seq, ChIP-seq and Advanced Chromosome Conformation Capture