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, construction and characterization of completely synthetic eukaryotic chromosomes. The group is actively exploring new applications of artificial chromosome technology, including the generation of novel natural
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of Medicine. The Meyer laboratory investigates mechanisms of cell-fate determination, genome editing, the role of chromosome structure and chromatin modification in gene regulation, and the molecular evolution
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-fate determination, genome editing, the role of chromosome structure and chromatin modification in gene regulation, and the molecular evolution of chromosome-wide mechanisms of gene control in
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proteins (NAPs) in the regulation of bacterial gene expression. NAPs bind DNA to organize bacterial chromosomes and increase their compaction. Binding of these proteins to DNA is believed to modify
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responsible for the mutation of oncogenes leading to chromosomal gene translocations and B cell malignant transformation. Therefore, understanding the basic molecular mechanisms involved in GC formation and
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-fate determination, genome editing, the role of chromosome structure and chromatin modification in gene regulation, and the molecular evolution of chromosome-wide mechanisms of gene control in
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Cytogenetics and Molecular Laboratory is staffed by approximately 18 technologists, two bioinformaticians, one post-doc and three faculty directors. The laboratory performs chromosome analysis, fluorescence in
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, or chromosome copy number changes, in cancer-related processes. We are looking to hire a computational biologist who will work closely with other scientists in the Sheltzer Lab to aid in the design and analysis
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group has used their expertise in computer simulations on small model chromosomes to demonstrate that polymer-assisted condensates are capable of maintaining the epigenetic state through 40 generations
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and connectivity of nucleosomes in chromatin that give rise to chromosome structure in cell nuclei and biochemical reconstitutions. This involves developing supervised and self-supervised AI models