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space. The outcome will provide fundamental insights into the dynamic structural interconversion of non-canonical nucleic acid systems, enabling the fine-tuning of gene expression and associated cellular
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CLL pathophysiology by providing survival and proliferation signals. BCR inhibitors targeting key BCR-associated kinases, such as BTK and PI3K delta, are highly effective as single agents in CLL but
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for understanding G4/ i-Motif biology in fine-tuning gene expression and alleviating associated cellular dysfunctions. The design of peptide-based G4/i-Motif inhibitors can be used in (a) epigenetic-driven anticancer
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function of the transcription apparatus can lead to the onset of blood cell malignancies. The abnormal function of TFs due to dysregulation or genomic aberrations are often associated with the development
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). The factors that drive aggressiveness or histological transformation remain poorly understood. The transformation has been associated with genetic alterations (such as mutations in TP53, MYC), epigenetic
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polymerization maintains the chromatin association of Polycomb proteins for the switch to epigenetic silencing. Molecular Cell 85, 3321–3332.e3325, doi:10.1016/j.molcel.2025.08.002 (2025). Fiedler, M. et al. Head