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and flow cytometry techniques • Viability and apoptosis assays • Protein analysis techniques using ELISA, multiplex, and western blot • RNA extraction from cells and tissues and PCR techniques
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assays (IC50), and mechanism of action tests (PCR, cell cycle analysis, apoptosis/necrosis detection, GSH levels, mitochondrial membrane potential, AP sites); • experience in analyzing results
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with 1+ year of specialized experience in adherent cells ? 3+ years of experience in mammalian cell health assays (e.g., viability, apoptosis, DNA damage) ? 3+ years of experience in mass spectrometry
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infections, and functional assays (e.g., proliferation, apoptosis, reporter assays). Conduct nucleic acid and protein analyses including qPCR, RT-qPCR, Western blotting, immunoprecipitation, and flow cytometry
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, triggering ER stress–mediated apoptosis and increasing susceptibility to proteasome inhibitors (4-8). Based on these findings, this thesis project aims to dissect how the nature, rate, and fidelity
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, epigenetics, cancer genetics, stem cell biology, genetically-engineered mouse, zebrafish models of cancer, apoptosis, DNA repair, cell motility, cancer metabolism, cancer data science and immuno-oncology. In
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of HIF on these. - Establish new methods/models to assess DNA damage and their consequences, in larvae or adults Please apply for this project using this link: https://www.sheffield.ac.uk/postgraduate/phd
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are uniquely prone to melanoma-genesis. We aim to identify pathways of apoptosis in melanocytes and melanoma cells, by gaining much needed new insights into how melanocyte precursors of melanoma become unstable
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their relevance to ALS disease mechanisms. For more information about the project, or to discuss a potential application, please contact Dr Chun Guo (https://www.sheffield.ac.uk/biosciences/people
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. Additionally, DDR protects stem cells from apoptosis, senescence, and premature functional decline. Impairment or failure of DDR—driven by congenital or acquired genetic variation or chronic cellular stress