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antibody specificity profiling. KEY RESPONSIBILITIES You’ll join a small team advancing a new screening platform focused on therapeutic antibody specificity. The aim is to deploy this newly developed assay
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the development and characterization of antibodies, antibody-drug conjugates, bispecific antibodies, or cell-based immunotherapies (e.g., CAR-T or CAR-NK). Experience in advanced molecular and cellular biology
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), potentially through antibody-dependent cellular cytotoxicity (ADCC). This project aims to investigate the pathophysiological role of CD8 TEMRA-mediated ADCC in individuals at the prodromal stage of PD
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the molecular mechanisms of bacterial virulence factors and translating these discoveries into macromolecular drug development—specifically focusing on antibodies, vaccines, and innovative medical cosmetics
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expression of a HIV-1 broadly neutralizing antibody (bNAb) in plasma for years without redosing. The systemic HIV-1 immunity achieved by this strategy could block acquisition of simian-HIV infection (SHIV) in
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parasite mutants, antibodies, spatial proteomics, real-time and super-resolution imaging, we will reveal essential protein domains and characteristics, will identify interacting protein partners and will
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and validate advanced methodologies for antibody characterization, such as ADE and ADCC assays, implement yeast-surface display for mapping antibody-antigen interactions, and establish systems
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understand the correlation between dengue vaccine protection and antibody enhancement. Unwanted/unsafe epitopes will be removed via viral engineering. Research skills in structural, engineering, and evolution
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experimental approaches for structural biology (e.g., cryo-electron microscopy/tomography, X-ray crystallography) is a significant plus. Experience with antibody engineering (e.g., expression, stability, binding
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duties as requested by the Principal Investigator or senior lab staff. Be Bold. Position Description: A HIV-1 Envelope (Env) vaccine that elicits broadly neutralizing antibodies (bnAbs) has remained