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their lifetime. Strikingly, the disease is twice as prevalent in Black men, often presenting earlier and with more aggressive features. Yet, most existing research focuses on white populations, leaving critical
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pathways. The project is particularly relevant to aggressive pediatric hindbrain cancers, which display profound epigenetic dysregulation yet paradoxically maintain relatively stable genomes. By linking
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aggressive form of brain cancer, characterized by diverse and dynamic cell states that drive treatment resistance and poor prognosis. In this project, funded by the Foundation Against Cancer, you will move
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common and aggressive primary brain tumor, for which effective therapies are still lacking. Your mission About the Project Our research has shown that approximately 99% of glioblastomas are positive
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Zurich, Basel) and the University Hospital Heidelberg / German Cancer Research Center (Heidelberg, Germany). Project background Glioblastoma (GB) is the most aggressive primary brain cancer in adults
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aggression, fear, and feeding), using large-scale neural recordings, advanced imaging, causal perturbations, and quantitative analysis in freely moving mice. For an overview of the lab’s research program and
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. The project is particularly relevant to aggressive pediatric hindbrain cancers, which display profound epigenetic dysregulation yet paradoxically maintain relatively stable genomes. By linking chromatin
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major risk factor for pancreatic cancer, which is one of the most aggressive malignancies and among the highest mortality rate of all cancers. Current projects in the lab are focused on investigating
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infrastructure. Our research focuses on the neural basis of prototypical behaviors, including aggression, defensive states, and parental care, using a combination of advanced behavioral paradigms, in vivo