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techniques. The findings will lay the groundwork for clinical application and contribute to the development of targeted therapies for resistant bacterial infections. Approach and Methods Atomic force
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plasmid efficacy against WHO-priority AMR gene analogues in relevant bacterial hosts Bioprocess optimisation: Develop high-cell-density cultivation protocols in bioreactors, addressing plasmid stability
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to develop nanoengineered, slippery surface coatings that prevent bacterial adhesion and biofilm formation on orthopaedic implants without relying on antibiotics or toxic metals. By precisely tuning surface
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. Synthetic analogues will be developed and screened alone and in combination with existing antimicrobials. The ultimate goal is to design novel chemotherapeutic combinations that disrupt cell wall remodelling
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rather than the structured biofilms found in real-world environments. This project investigates how engineered surface topographies influence HGT dynamics, aiming to develop design principles for materials
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, more effective medical devices and reduce reliance on antibiotics, contributing to global AMR mitigation efforts. Training and Student Development: The student will gain interdisciplinary training in
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Engineering, Physical Sciences, and Mathematical Sciences. Why chose UCL? UCL has a history of academic excellence and is consistently ranked among the world's top universities, with many of our faculties