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, 33621493, 33087936, 30566856, 39947938; doi: https://doi.org/10.1101/2025.03.15.641049 ). Postdoctoral Projects Project 1: Replisome Dynamics, Replication Stress, and Cancer Vulnerabilities This project aims
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maintaining transgenic mouse lines including blood collection, ear tagging, and tail clipping. Experience in laboratory management, such as ordering supplies, preparing reagents, and maintain lab organization
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conducting electrophysiological, histological and behavioural research in transgenic model animals at the Department of Physiology IP PAS. Department Head: Professor Krzysztof Tokarski, PhD KEYWORDS
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(IDH1/2) genes and this project focusses on how these mutations re-program liver cells, in the context of biliary cancer. We are using CRISPR-edited human cells and novel transgenic models in mice
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senior members of the team. What you would be doing Work will involve a combination of innovative techniques including genetic library-based screening, imaging and dedicated transgenic model organism work
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imaging, human tissue organoids, CAR-T cells, CRISPR–Cas9–guided gene or epigenetic editing, and inducible transgenic models targeting dendritic cells, tissue-resident macrophages, the tissue niche, and
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of mouse models. Working with laboratory animals (e.g., rodents). Involvement in maintaining transgenic mouse colonies and performing essential procedures. Conduct independent research under guidance: Pursue
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requests from researchers, plant care, cleaning, and routine maintenance. Conduct lab data collection as well as field trials measurements in conjunction with associated researchers. Dispose of transgenic
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on chronobiology and neuroscience related research projects. Manage transgenic and knockout mouse colonies, pup weaning and genotyping. Maintain adequate inventory of laboratory supplies; order and organize
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: Maintain and manipulate transgenic or knockout mouse lines relevant to neurodegeneration. Perform behavioral, histological, and molecular analyses on brain and spinal cord tissues. • Perform Molecular and