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biochemical reconstitution, electron cryomicroscopy (cryo-EM), advanced bacterial genetics, and phage biology to explore how cells and viruses control the three-dimensional structure of DNA. We investigate how
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at the Department of Biochemistry. You will be working on a project that will study the functional importance and prevalence of filamentation among transcription factors at the structural level. The project has a
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relevant skills acquired and will also be determined by the funding available. About you Applicants will hold a PhD/DPhil or be near completion of a PhD/DPhil in a subject relative to Structural Biology
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in Mass Spectrometry and Structural Glycobiology to work under the supervision of Prof. Weston Struwe for a period of 24 months. The project, funded by the UKRI, centres on developing advanced methods
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remains poorly understood. It is also unclear how the conformational landscape of dynein-2 is affected by diseases mutations. This project involves using a multi-scale structural biology approach, involving
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generate key structural and biophysical data to support the design of small molecule inhibitors with particular focus on protein production and crystallisation, solving protein-ligand structures, fragment
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approaches, as well as being able to build on expertise in bacteriology, cell biology, structural biology and biochemistry in the group. You should hold, or be close to completion of, a PhD/DPhil in biological
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including protein purification, SDS-PAGE, and western blotting. The post holder should be familiar with bioinformatics tools and databases (BLAST, protein structure prediction tools) and have basic
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research projects require a creative, multidisciplinary approach, and as such provide opportunities across parasitology, structural biology, biochemistry and cell biology including single molecule
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and structural biology of rhomboid-like membrane proteins. You should hold a PhD/DPhil in a topic relevant to structural biology and biochemistry, together with relevant experience. You should be able