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biochemical reconstitution, electron cryomicroscopy (cryo-EM), advanced bacterial genetics, and phage biology to explore how cells and viruses control the three-dimensional structure of DNA. We investigate how
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at the Department of Biochemistry. You will be working on a project that will study the functional importance and prevalence of filamentation among transcription factors at the structural level. The project has a
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relevant skills acquired and will also be determined by the funding available. About you Applicants will hold a PhD/DPhil or be near completion of a PhD/DPhil in a subject relative to Structural Biology
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in Mass Spectrometry and Structural Glycobiology to work under the supervision of Prof. Weston Struwe for a period of 24 months. The project, funded by the UKRI, centres on developing advanced methods
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remains poorly understood. It is also unclear how the conformational landscape of dynein-2 is affected by diseases mutations. This project involves using a multi-scale structural biology approach, involving
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generate key structural and biophysical data to support the design of small molecule inhibitors with particular focus on protein production and crystallisation, solving protein-ligand structures, fragment
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approaches, as well as being able to build on expertise in bacteriology, cell biology, structural biology and biochemistry in the group. You should hold, or be close to completion of, a PhD/DPhil in biological
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and structural biology of rhomboid-like membrane proteins. You should hold a PhD/DPhil in a topic relevant to structural biology and biochemistry, together with relevant experience. You should be able
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research projects require a creative, multidisciplinary approach, and as such provide opportunities across parasitology, structural biology, biochemistry and cell biology including single molecule
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the methodology and experimental approaches, as well as being able to build on expertise in bacteriology, cell biology, structural biology and biochemistry in the group. You should hold, or be close to completion