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chromosome 8p that results in neurodevelopmental delays, epilepsy, and other clinical features. Using our recently developed chromosome engineering approach, we have created isogenic stem cell lines that allow
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statement when you apply. Criteria Essential or desirable Stage(s) assessed at PhD (or equivalent experience) in a relevant subject area such as stem cell biology, molecular biology, developmental biology, or
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. Nanomaterials 2023, 13, 1190. https://doi.org/10.3390/nano13071190 Mesenchymal Stromal Cell-derived Extracellular Vesicles in Wound Healing Supervisor: Catherine Berry MSc choices: Stem Cell Engineering for
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investigating tertiary lymphoid structures in inflammatory diseases, interorgan endocrine signaling, the comparative niches of stem cells across tissues, or mechanisms of transcriptional regulation such as
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their anticancer and neuroprotective activities in human cell-based assays. Generate SAR data linking specific enzymatic modifications to pharmacological properties. This PhD project offers extensive research
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neurons using multi-omics, cis-regulatory variants will be mapped onto these enhancers and then their function determined by Massively Parallel Reporter Assays (MPRA). The research will involve stem cell
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using stem cell differentiation. The interaction between these cell types will be studied in co-culture and characterized using live-cell imaging, transcriptomic and proteomic profiling
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collaborative abilities Strong interest in Development or cancer biology or stem cells, and molecular mechanisms. Skills in cell culture, molecular biology, or bioinformatics are a plus. Excellent English level
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a Ciência e a Tecnologia, IP.P. / MCTES through national funds (PIDDAC). Scientific Area(s): Developmental Biology and Stem Cell Biology Fellowship recipients / Admission requirements: Any National
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/ . The Yachie lab (https://yachie-lab.org/ ) develops next-generation molecular technologies that integrate DNA event recording, genome engineering, organoid and stem-cell platforms, and high-throughput