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to identify candidate disease-causing variants. You will develop model systems, e.g. genome-editing of immune or induced pluripotent stem cells (iPSC) with specific patient-derived genetic variants. We aim
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We are seeking an enthusiastic and highly motivated Postdoctoral Research Associate to join the Birket Lab, an ambitious team pioneering research in human pluripotent stem cell (hPSC) biology to
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hematopoietic stem cell transduction. Experiments will range from in vitro demonstration of antigen-specific transduction of candidate cell subsets under various culture conditions, to testing their anti-tumor
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Post-doctoral Fellow in the Department of Orthopaedics and Traumatology, School of Clinical Medicine
) to model orthopedic pathologies. Manage and perform functional studies using animal models (e.g., transgenic mice) to evaluate disease progression and therapeutic efficacy. Utilize induced pluripotent stem
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of cellular senescence, including senescence in stem cells, and identifying novel approaches to reduce the senescent cell burden. The candidate will join an exciting research environment in
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of novel therapeutics (e.g. stem cell-based, RNA therapeutics) to accelerate cardiac regeneration and treat heart failure. Chronic heart failure remains an unmet clinical need. As the heart is the least
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release of cell therapy products. At UCI, the cGMP facility will enable clinical trials of cell therapeutics, including stem cell populations and bone marrow transplantation, as well as Chimeric Antigen
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Therapies Donor Services Specialist facilitates allogeneic donor identification and collection processes on behalf of adult and pediatric patients undergoing a stem cell transplant or other Cellular Therapy
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related to these general topics. Each focuses on gene regulation â“ and changes that occur in gene regulation â“ during stem cell development and differentiation. We use mice to model pediatric malignancies
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, optogenetics, genome engineering, induced pluripotent stem cell differentiation to neurons/organoids, and in vitro and in vivo electrophysiological measurements. Our long-term scientific goal is to dissect