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NEDD4-1 and NEDD4-2 expression and function in human stem cells and dopaminergic neurons in culture as well as in human and mouse brain sections under physiological and pathophysiological conditions. We
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to Biochemistry, Biomedical Sciences, Pharmacology and Genetics. Applicants with experience in pluripotent stem cell or primary cancer cell culture, and/or organoid systems are particularly encouraged to apply
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. Using gastruloids as a model system with which to study GAG structure/function relationships. Generating gastruloids from induced pluripotent stem cells (iPSCs) to create in vitro models for studying
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from induced pluripotent stem cells (iPSCs) to create in vitro models for studying critical steps of gastrulation and early development. Creating iPSC lines with mutations in elements of the GAG
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and stem cell biology. The study investigates how APOE4 expression in endothelial cells affects oligodendrocyte progenitor cells (OPCs), using iPSC-derived 3D co-culture models. This work aims to
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hepatic dysfunction in Alpers’ syndrome. The proposed studentship will involve a multi-disciplinary mechanistic approach harnessing induced pluripotent stem cell (iPSC) in vitro models and a unique resource
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. Generating gastruloids from induced pluripotent stem cells (iPSCs) to create in vitro models for studying critical steps of gastrulation and early development. Creating iPSC lines with mutations in elements
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. This primarily stems from the challenging materials (large/disordered unit-cells, long sampling timescales) and light-matter interactions involved. Consequently, computational tools, rooted in physics, that can