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at the Department of Laboratory Medicine within the Faculty of Medicine studies how hematopoietic cell fate is specified, maintained, and eventually modified or reversed. Inspired from the fields of stem cell biology
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, mesenchymal stem cells and patient‑derived chondrocytes. You will join Newcastle University’s Faculty of Medical Sciences, with access to state-of-the-art facilities and specialist training in genomics
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PhD Studentship: Preclinical modelling and therapeutic targeting of glioblastoma infiltrative margin
infiltrative margin will be re-programmed to generate induced pluripotent stem cells as a patient-matched toxicity control. Research Environment: Applications are invited for a 4-year fully-funded PhD
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their anticancer and neuroprotective activities in human cell-based assays. Generate SAR data linking specific enzymatic modifications to pharmacological properties. This PhD project offers extensive research
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. To address these questions, the student will use isogenic SARM1 knock-in human induced pluripotent stem cells (iPSCs) with GoF mutations (E340K, del275-276 and A275V), SARM1 knockout and a homozygous intronic
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:10.1038/s41551-022-00951-w Investigating the role of autophagy and mitochondrial function in leukaemic stem cells Supervisors: Vignir Helgason , Eric Kalkman Our lab is interested in biological processes
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: Refinement of Stem Cell-Based Strategies for Ischemic Lesion Recovery” (reference: RESCUE #1), funded by the Portuguese Foundation for Science and Technology (FCT) under Call MPr-2023-12, taking place at RISE
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, research is vital to advance diagnosis, treatment and prevention. Our strength is in identifying and designing novel therapeutic strategies that will lead to clinical trials. PhD: 3-4 years full-time; 5