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BBSRC Yorkshire Bioscience DLA Programme: Human Stem Cell-Based Approaches for Neurotoxicity Testing of Environmental Contaminants (CASE Project) School of Biosciences PhD Research Project
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differentiation models. Applicants should hold (or be close to completing) a PhD in molecular biology, stem cell biology, genetics or a related discipline, with strong technical skills in cell and molecular biology
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Stem cell therapies offer a new therapeutic paradigm in regenerative medicine. Bioengineering approaches can help to deliver specialised cells targeting specific clinical challenges, yet there
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stem cells (satellite cells) can be guided by anatomical and environmental signals to generate muscle fibers that are more resistant to disease. Using a unique collection of genetically engineered
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Leukemia DC15: Novel preclinically-validated GATA3 inhibitor/degrader as a therapy for T-cell Acute Lymphoblastic Leukemia DC16: Targeting Metabolic Pathways in Leukemic Stem Cells for AML Treatment
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-funded research projects, this position provides support in the operation of the research laboratory. The responsibilities will include preparation of human stem cell cultures from repository specimens
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or induced pluripotent stem cells (iPSCs) derived from patient peripheral blood mononuclear cells. Validation will include stimulating or inhibiting target pathways using antagonists or agonists, or using gene
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of scientific publications in relevant fields. Experience with models of myopathies or inflammation. Familiarity with stem cell-derived muscle models or 3D culture systems (including physiological
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hours as appropriate. Qualifications PhD in stem cell and regenerative biology or cell and molecular biology or a closely related field and/or an equivalent graduate degree plus at least five years of
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with an emphasis on translational application and therapeutic development. The Cornea Biology Laboratory, under the direction of Sophie Deng, MD, PhD, studies corneal stem cells aiming to develop novel