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Field
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this disease and reveal the mechanisms underlying the strong cell-type specific effect of the CMT-causing YARS mutations. For this we will generate high-resolution spatial chromatin organisation, chromatin
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an integrative approach that combines advanced multiomics, spatial transcriptomics, and structural biology with physiological assessments. By selectively perturbing key gene expression programs during homeostasis
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Earth system models on different temporal and spatial scales to answer key questions of global change. Doctoral candidates of the IMPRS-ESM contribute to the development and application of Earth system
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help manage and contribute to our program in ex vivo human cell biology and in vivo rodent models, focused on deciphering the cellular and molecular basis for neurodegenerative diseases, including
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. At the Copernicus Institute, the Amazon rainforest and its spatially cascading transitions have been studied for years using custom made data analysis and modelling methods. Within the NWO-Summit project EMBRACER
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instance learning and weak supervision / spatial transcriptomics models to individualise tumour type, associated biomarkers and genomic characteristics to high precision. The resulting multipurpose machine
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) typically lack simultaneous nanoscopic spatial resolution, which is necessary to track individual atomic motions, and (ii) are unable to capture stochastic events like ion-hops or lattice fluctuations which
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possible shift (temporal and spatial) in rainfall patterns across the MLR (climate change/water) Explore various River Murray hydrological, hydraulic modelling questions (River Murray/water) Review economic
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. Defining predictive tasks based on clinical goals. Selecting and setting up appropriate data preprocessing pipelines. Training and evaluation of computer vision models. Internal and external algorithmic
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) developing (new) GeoAI methods to enable fine-grained spatial data modelling of street environments, 2) elucidating the contribution of geographic environment to crimes and crime diversity, 3) large-scale