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. Volkers M, Loughrey CM, Macquaide N, Remppis A, DeGeorge BR, Jr., Wegner FV, Friedrich O, Fink RH, Koch WJ, Smith GL, and Most P (2007) S100A1 decreases calcium spark frequency and alters their spatial
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an integrative approach that combines advanced multiomics, spatial transcriptomics, and structural biology with physiological assessments. By selectively perturbing key gene expression programs during homeostasis
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., Wegner FV, Friedrich O, Fink RH, Koch WJ, Smith GL, and Most P (2007) S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes
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immunology through innovative spatial analysis of the tumor microenvironment. Requirements Successful candidates will have a PhD, MD, or equivalent degree in immunology, cancer biology, pathology, or a related
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clinical prediction of progression remains difficult, leading to over- and undertreatment of women with particularly early breast cancer. Over the past decade, spatial tissue analysis techniques have been
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mechanisms involving genetic, epigenetic and chromatin organisation factors governing the cell-type specific response to ARS mutations. Therefore, integrative genome-wide cis-regulatory network analysis
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or local scales due to spatial, temporal, and sectoral heterogeneities. Moreover, the availability and quality of energy-related models and datasets at these levels are often limited, further complicating
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monitoring Statistical analysis and modelling of relevant data (e.g. environmental data). Publishing results in peer-reviewed scientific journals. Fisheries management and conservation (e.g. biodiversity
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. At the Copernicus Institute, the Amazon rainforest and its spatially cascading transitions have been studied for years using custom made data analysis and modelling methods. Within the NWO-Summit project EMBRACER
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-regulatory network analysis approaches, developed and employed in the Malysheva Lab, are required to reveal these mechanisms. With the proposed project we aim to bridge this gap in our knowledge of cis