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approach: integrating mechanical and enzymatic antibiofilm mechanisms into medical-grade polymers to create next-generation single-use medical consumables with built-in, robust antibiofilm properties. By
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robotic automation to identify and optimise lead compounds. This approach will serve as a test case for a generalisable platform for rapid, structure-guided antiviral discovery. Approach and Methods
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targeting AMR gene suppression AI-driven genome design: Use LLM tools (e.g. PlasmidGPT, Evo2) to refactor plasmid genomes for enhanced manufacturability, safety, and performance Microbial validation: Test
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principles molecular dynamics simulations. You will contribute to the development of novel work flows as well as to the training, testing and application of latest neural network methodologies. Applications
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wall metabolism and membrane integrity Design and synthesise small libraries of peptide analogues Screen compounds against drug-susceptible and drug-resistant clinical isolates Develop combination
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testing, with clinical input from RNOH to ensure translational relevance. Approach and Methods: Design and fabricate porous, nanoengineered surfaces with anti-adhesive, slippery properties Characterise
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PhD Studentship: Nanopore Technology for Rapid and Accurate Measurement of Antibiotic Concentrations
for small-molecule sensing. By engineering nanopores with molecular recognition elements such as DNA aptamers, this project will enable multiplexed, real-time detection of diverse antibiotics, supporting both
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Abstract: Antibodies are a rapidly expanding class of therapeutics with applications in infectious disease, cancer, and immunotherapy. Among them, bovine antibodies with ultralong complementarity-determining
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could be applied in biotechnology, healthcare, and environmental contexts. Employ synthetic and molecular biology tools to design and test new methods of controlling fungal behaviour. Impact and Outlook
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pharmaceutical R&D Application of AI in process development and materials discovery Antimicrobial testing and biological evaluation Workflow integration and data management for self-driven laboratories Project