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: Machine Learning Molecular Dynamics. The project involves the development and application of machine learning methods that enable a major boost of the time and length scales accessible to ab-initio/first
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. Approach and Methods: Apply deep learning-based modelling and clustering to analyse a curated dataset of hundreds of thousands of UL-CDR sequences Characterise sequence–structure relationships and structural
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that block infection at its source, with broad applicability to respiratory pathogens, including drug-resistant bacteria. Approach and Methods: Use automated synthesis platforms to generate a high-throughput
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(SONATA, EP/V028626/1) and brings together expertise in microfluidics, fluid dynamics, nanoparticle engineering, and dental microbiology. Approach and Methods: Engineer in vitro models of bacterial biofilm
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techniques. The findings will lay the groundwork for clinical application and contribute to the development of targeted therapies for resistant bacterial infections. Approach and Methods Atomic force
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genomics, microbial ecology, and bioinformatics, the project will generate a curated catalogue of phages host relationships, and enzymes for future experimental validation. Approach and Methods Metagenomic
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robotic automation to identify and optimise lead compounds. This approach will serve as a test case for a generalisable platform for rapid, structure-guided antiviral discovery. Approach and Methods
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disinfectants. With antimicrobial resistance (AMR) on the rise, there is an urgent need for non-antibiotic strategies to prevent and control biofilm formation on medical devices. This PhD project proposes a novel
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testing, with clinical input from RNOH to ensure translational relevance. Approach and Methods: Design and fabricate porous, nanoengineered surfaces with anti-adhesive, slippery properties Characterise
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Supervisors: Dr. Maximilian Besenhard Dr. Maryam Parhizkar Abstract: Antimicrobial peptides (AMPs) are natural molecules produced by the immune system and represent one of the most promising avenues for developing new treatments against drug-resistant infections. Their rapid action and ability...