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Development and application of new methods for studying allosteric regulation in chaperone complexes
and the regulation of protein levels and activities in cells, and the use of the resulting information to design new molecules capable of allosterically regulating these processes. The researcher's work
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techniques of cryo-electron microscopy (cryo-EM), small angle X-ray scattering (SAXS), single-molecule force spectroscopy (SMFS), biochemistry, mutational analysis, cell culture, activity assays, et cetera
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.-Investigating interactions with lipid bilayers and vesicles.-Observing motor motion and evaluating performance with single-molecule localisation fluorescence microscopy. We are looking for candidates who have:-A
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the connections between microtubule motors and their cargos. The scope of the project can involve in vitro reconstitutions, single-molecule assays, cryo-electron microscopy and cell biology approaches using induced
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key platform molecules, 5-hydroxymethylfurfural (5-HMF) offers exceptional potential for the production of bio-based polymers, fuels, and fine chemicals. However, conventional catalytic oxidation routes
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that are properly folded and competent for protein translation. Force spectroscopy (optical and magnetic tweezers), single-molecule fluorescence, and bulk biochemical methods will be used to investigate how
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) microscopy, multiphoton microscopy, intravital microscopy, cleared tissue light sheet microscopy, single molecule localization microscopy, stimulated emissions depletion (STED) microscopy. Application
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I position is available in the RSP Lab led by Dr. Sklavenitis Pistofidis. The RSP Lab (https://rsplab.org ) leverages advanced multi-omic technologies, coupled with experimental perturbations and
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. Research directions may include: Quantitative mechanical measurements of single molecules, cells, nuclei, and tissues AFM-based force spectroscopy, indentation, and correlative AFM–confocal approaches
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project, which aims to explore the potential of paramagnetic complexes as solid-state quantum bits (qubits) for quantum information processing. In order to measure properties at the single-molecule scale