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analytical methodologies to investigate disease-relevant structures and mechanisms across all biological scales - from single molecules to entire organisms. Our vision is to translate fundamental discoveries
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that are specifically for cancer cells to capture and bind specific surface marker EpCAM and cancer cell-specific glycoproteins and molecules as novel liquid biopsy tools. The nano-antibodies-captured cancer cells will
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². Understanding how these repeat sequences alter DNA structure and affect DNA-binding proteins is key to developing targeted therapies. In this project, you will use state-of-the-art single-molecule techniques
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that maintain genome integrity. We are among the few labs worldwide that integrate cellular and electron microscopy techniques to investigate changes in replication fork dynamics at the single-molecule resolution
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based on the intriguing properties of the quantum world. Applications include single-molecule and precise field sensing, quantum computing, single-particle emission/detection, twistronics and so
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study single atoms and molecules on surfaces, and by doing so, contribute to understanding how electronic properties emerge at the smallest length scales, we look forward to hearing from you! About us We
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, the candidate will address how mRNA translation contributes to germ granule biphasic architecture and biophysical properties. - Drosophila genetics - Molecular biology - Advanced imaging (super-resolution, single
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mutation detection using third-generation single-molecule sequencing’ in the Department of Paediatrics, Yong Loo Lin School of Medicine. Department of Paediatrics is committed to the advancement
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and their implications for secondary metabolite production. We use a wide range of approaches: protein biochemistry and reconstitution, single-molecule biophysics, proteomics, metabolomics, fungal
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, biochemistry, biophysics, and cancer biology. Techniques include single-molecule localisation microscopy, CRISPR genome editing, and protein biochemistry. The project also involves in vivo tumour xenografts