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multidisciplinary project applying chemical synthesis and biological testing to design, synthesise and biologically evaluate new small molecules which can interfere with arginine-dependent tumours. The general
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Hydrogen is the most abundant molecule in the universe, and its interaction with surfaces plays a key role in a huge range of processes, from star formation to the safe storage of rocket fuel
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structural molecules. Unravelling the ways in which these motifs are encoded into GAGs by their biosynthetic machinery is the fundamental challenge behind the BBSRC-funded GlycoWeb project. This 4-year PhD
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Proteins are key biomarkers, indicative of normal biological or pathogenic processes and responses to intervention. Identification and quantification of such molecules in biological fluids is
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utilities mostly for corrosion protection of the secondary circuit components.[1] FFA are molecules with a hydrophobic tail (carbon chain) and a hydrophilic head (usually a NH2 group). Injected in the side as
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specific motifs within the glycan chains defining binding sites for critical signalling and structural molecules. Unravelling the ways in which these motifs are encoded into GAGs by their biosynthetic
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. The subsequent data will then be used to populate machine learning models to predict which molecules to synthesise next, to maximise the binding affinity of the molecules to a target protein. This research aims
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PhD Studentship: Dissecting the Molecular Architecture and Function of LMTK3 as a Therapeutic Target
; University of Sussex | The City of Brighton and Hove, England | United Kingdom | about 1 month agothe crystal structure of the LMTK3 kinase domain and developed the first-in-class small-molecule inhibitor, C28. Despite these significant advances, a comprehensive understanding of the full-length LMTK3
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computational and machine learning approaches to integrate Oxford Nanopore (ONT) long-read data with bulk and single-cell RNA-seq profiles. The aim is to identify host-microbiome molecular signatures that drive
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associated with chemistries used for industrial processes, the synthesis of new inhibitory molecules proves extremely challenging. Recent research has resulted in the synthesis of a new class of chemistries