6 signal-processing PhD scholarships at International PhD Programme (IPP) Mainz in Germany
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interactions and signaling pathways will then be extrapolated to existing single-cell RNAseq libraries of type 2 immune patients. This PhD requires a strong background in immunology, previous experience with
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that contribute to the aging of the hematopoietic system. Proteases of the coagulation system have been implicated in the regulation of the fate of HSC (extravascular coagulation signaling) in homeostatic condition
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step in eukaryotic gene expression, ensuring that mature transcripts are delivered from the nucleus to the cytoplasm for translation. Multiple challenges are faced in this process: How are mRNAs
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) are important mediators of most cellular processes. Understanding how proteins interact with each other, ideally at structural resolution, is key in understanding molecular processes, how disease mutations would
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translocases have been shown to regulate R-loop levels in cells. In recent years, R-loops have been recognized as a major cell-intrinsic source of genomic instability, and dysregulation of R-loop processing is
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longer-term immune responses. Specifically, they play key roles in pathogen recognition, antigen uptake, processing and presentation, but also contribute to tissue homeostasis, tolerance to commensal