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signals and initiate downstream responses, with a particular emphasis on the mechanistic basis of activation and small molecule modulation. We investigate pathways involving cytosolic DNA sensors
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available single-cell sequencing data generated from patient samples and mouse models, we will enhance and apply machine-learning based algorithms to deconvolute bulk tumor RNA-seq samples to distinct immune
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interdisciplinary teams to apply developed algorithms to real-world datasets and generate valuable biological insights. Perform integrative analyses of multidimensional datasets within the context of basic immunology
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. The most recent methodological research of the group includes algorithms for cell type deconvolution, high-resolution purification, and integration of single cell multi-omics data. This postdoctoral fellow
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, focusing on its roles in metabolic pathways essential for biosynthesis and redox balance. Our work explores how p53 functions as both a sensor and regulator of cellular metabolism. We are also identifying
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health and disease, and experience in the algorithms used to analyze these datasets. The appointee will ultimately create an independent research effort with dedicated extramural funding that complements
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activity in ulcerative colitis patients with transcriptional changes in a longitudinal patient cohort, develop deconvolution algorithms, extract features from H&E sections etc. Bacterial metabolism and host