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several types of spatial growth patterns which correlate with therapy efficiencies and overall survival (Vermeulen et al. J Pathol. 2001 , Nielsen et al. Mod Pathol. 2014 , Baldin et al. J Pathol Clinical
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the causal circuits driving the development and the functional specialisation of the largest macrophage population in the body: the liver-resident Kupffer cells. You will next develop Spatial CRISPR screens in
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. This research project has a dual focus. On the one hand, you will be involved in analysis of spatial, single-cell and multi-omics data to efficiently characterize the different molecular layers. This will be done
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ample opportunities for direct validation in biologically relevant settings. This interdisciplinary atmosphere has been a main catalyst for many past successes: https://europepmc.org/article/MED/35021063
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catalyst for many past successes: https://europepmc.org/article/MED/35021063 , https://europepmc.org/article/MED/31819264 , https://europepmc.org/article/MED/31561945 , https://europepmc.org/article/MED