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Overview A hexanucleotide expansion mutation in the C9orf72 gene is the most common genetic cause of Amyotrophic Lateral Sclerosis (ALS). There are three proposed mechanisms leading
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research programme is to use genetic, molecular and cellular, and imaging/image analysis approaches to understand the development and function of the vertebrate inner ear, the organ of hearing and balance
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Evolutionary genetics in a wild mammal population
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this using in vivo two-photon calcium imaging, confocal microscopy, stochastic genetic labelling of single neurons, and detailed analysis of neuronal morphology. You will design, develop and perform
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. The successful applicant will use a variety of imaging and computational image analysis techniques to generate a 3D morphometric atlas of post-embryonic stages of otic development in the wild-type zebrafish, with
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argon. The analysis of the ProtoDUNE data will help to validate calibration techniques and particle identification algorithms. The candidate should have a good knowledge of particle physics and experience
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A search for pharmacological inhibitors of a cancer-associated adhesion GPCR in the zebrafish embryo
to identify and improve key pharmacological properties of selected compounds of interest. The student will also have the opportunity to test for increased tumour risk in a new adgrg6 genetic variant. We
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Computational Fluid Dynamics modelling of free surface flows over packing materials in a CO2 absorber School of Mechanical, Aerospace and Civil Engineering PhD Research Project Self Funded Prof
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. Further characterisation of these fibroblasts and comparison between different types of HNC (oral, oropharyngeal and laryngeal) has the potential for therapy as fibroblasts remain genetically stable unlike
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safety. Led by Professor Mimoun Azzouz, The GTIMC at Sheffield is dedicated to advancing the clinical development of new genetic treatments options for millions of patients with life-threatening diseases