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disorders. We will test the hypothesis that experience results in structural modifications to cells that alter neural circuit connectivity patterns that in turn modify behaviour. The brain is made up
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been enhanced through predictive structural biology tools such as AlphaFold, which allow accurate prediction of effector structures from primary sequence. We recently identified a number of immune
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Main description: Native mass spectrometry is an expanding structural biology tool to elucidate the function of protein complexes. Excitingly, the demand for this technology is increasing. However
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will sit within the Department of Applied Health Sciences and will support the delivery of the NIHR Research Professorship awarded to Professor Joht Singh Chandan (NIHR306365, https
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they will develop synthetic skills in organic and coordination chemistry, analytical skills in the collection, analysis and interpretation of key data using a range of techniques to characterise structures
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disorders. We will test the hypothesis that experience results in structural modifications to cells that alter neural circuit connectivity patterns that in turn modify behaviour. The brain is made up
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irradiated materials. This work will be under the supervision of Prof. Enrique Jimenez-Melero, UKAEA Joint Chair in Materials for Fusion (https://www.birmingham.ac.uk/staff/profiles/metallurgy/jimenez-melero
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, such as reservoir construction, urban expansion, water abstraction, and wastewater discharge, are key drivers of changing hydroclimatic patterns (Han et al., 2022; Sarojini et al., 2016). However, our
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considering equilibrium or out of equilibrium systems, strongly correlated and/or non-Abelian settings, and how these structures manifest in realistic, experimentally relevant platforms. The work will include
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’, adopting distinct structural forms each tailored to functionally specific downstream targets. Initial cryo-electron microscopy (cEM) studies show that MRFAP1 forms a remarkable dodecameric ‘nanocage’ which