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concerns about external validity and equity, as underserved groups are often underrepresented due to restrictive eligibility criteria and structural barriers to participation. Even when included, patient
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allow researchers to explore alternative approaches. Target trial emulation is a structured framework to design observational studies that mimic randomized controlled trials, while reducing methodological
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heroin self-administration. Analyze synaptic mechanisms using western blot, RT-qPCR, immunohistochemistry, and electrophysiology (in collaboration). Characterize structural adaptations (dendrites, spines
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s'appuieront sur des expériences originales menées dans la chambre de simulation CESAM du LISA (https://cesam.cnrs.fr/ ), une infrastructure de classe mondiale permettant d'étudier les aérosols dans des