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. The work focuses on how oxidative stress, mitochondrial dysfunction and impaired mitophagy contribute to neuronal dysfunction and degeneration across disease progression. By combining advanced molecular and
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impaired mitophagy contribute to neuronal dysfunction and degeneration across disease progression. By combining advanced molecular and cellular assays with in vivo metabolic, ultrastructural and behavioural
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ubiquitylation (http://www.ppu.mrc.ac.uk/). Many world-leading researchers in the field of signal transduction have trained within the MRC PPU. The major aims of the MRC PPU are to advance understanding
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