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approaches, including: •cryo-electron microscopy (cryo-EM), •X-ray crystallography, • biophysical analyses of protein–DNA interactions (EMSA, ITC, BLI, HeliX). This is a fundamental research project — focused
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in any of the following methods will be advantageous: Single-crystal crystallography, Powder X-ray diffraction, NMR, UV-vis, IR and Luminescence spectroscopy, electrochemistry. The candidate will hold
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by SLX4 and its associated endonuclease partners, nothing was known about the attenuation of MMR raises important questions. The PhD student will use cryoEM, X-ray crystallography, and AI tools
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Andrew Lovering X-ray crystallography. Thus, overall once completed, we envisage the PhD student will have an excellent all-around knowledge in structural biology and have the ability to apply native mass
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, biochemistry, AlphaFold and structural characterisation by X-ray crystallography and cEM. Firstly, this will provide insights into new regulatory mechanisms relevant to several fundamental signalling pathways
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biochemical and biophysical methods to study the structure, function and dynamics of proteins. A special focus is on new methods within structural biology that utilize X-rays from synchrotrons and XFELs
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elucidation of atomic and electronic structures, and physical properties. The group is in possession of state-of-the-art diffraction instrumentation and single-crystal electron and X-ray crystallography, and
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laboratory PDF diffractometer, including the optimization of measurement protocols and combined mass spectrometry Experiments at synchrotron radiation facilities Analysis of powder X-ray diffraction (PXRD) and
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, Computational physics , Condensed Matter Experiment , Condensed Matter Physics , Condensed Matter Physics; Condensed Matter Theory; Computational Physics; X-ray Spectroscopy; Electronic Structure; Ultrafast
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at the participating laboratories, including platforms for NMR, X-ray crystallography, cryo-EM, and light microscopy; the Genome Centre with next-generation sequencing technology; and the Proteome Centre Tübingen