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of these candidates to determine how they regulate pericyte specification. For all projects, we routinely develop and apply cutting-edge approaches, including conditional genetics, CRISPR-based gene editing, single
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data. We have developed in vivo single-cell CRISPR technologies to screen for dozens of molecular factors in vivo during developmental and disease. These technologies are a game-changer in the speed
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candidate will undertake a three-year research project using a combination of expression screening techniques and loss-of-function CRISPR screening approaches with the goal of: (1) identifying substrates
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engineering (CRISPR/Cas), qPCR, and work with reporter lines carry out phenotyping, imaging, and hormone-related assays/tracing contribute to transcriptomic/proteomic experiments and integrative analysis
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-ISCIII (PI24/00173)", with the destination being the Foundation for Health Training and Research of the Region of Murcia. Where to apply Website https://rrhh.ffis.es/rrhh/ofertaEmpleo.jsf?id=1944
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viral vectors, CRISPR-based tools and pharmacological approaches. -Perform bioinformatic analysis and integration of transcriptomic, epigenomic and epitranscriptomic datasets. -Prepare scientific reports
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, protein biochemistry, electron and fluorescence microscopy and CRISPR/Cas9 genome editing to study the role of the early autophagy machinery in targeting and degrading protein aggregates and organelles
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, including gene expression analyses, lineage tracing, live imaging, and CRISPR-mediated gene manipulation to probe molecular and cellular mechanisms driving the development of molluscan brains and body plans
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machinery involved by combining these expression screens with loss-of-function CRISPR/Cas9 screens. Detailed follow-up of individual pathways of interest is achieved through a variety of standard genetic and
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www.psb.ugent.be for more information. Jenny Russinova lab at PSB focuses on research on brassinosteroid hormones (https://www.russinovalab.be ). Job description Brassinosteroids are steroidal phytohormones