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the development of genetic autoinflammatory diseases. Using techniques in cell biology, molecular biology and biophysics you will investigate how loss of function of the RNA editing enzyme ADAR1 causes the human
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to neurodegenerative diseases of the central and peripheral nervous system, with an emphasis on understanding the genetic etiology and developing diagnostics and treatment methods for these diseases. Approaches range
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developing genetic risk scores as biomarkers for neurological disorders. The Rademakers lab leads cutting-edge research into risk genes and molecular mechanisms in Frontotemporal Dementia (FTD), while
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and Saeys teams. In this research project you will develop and apply algorithms to link clinical phenotypes of metastasis to molecular phenotypes in mouse models. It is known that metastases exhibit
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mouse models with genetically engineered timing of synaptic development This work will contribute critical insight into how early brain development influences behavioral outcomes in ASD, and how