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promising targets for antiviral drug development. While the COVID-19 pandemic highlighted the threat of RNA viruses, large DNA viruses such as African Swine Fever Virus (ASFV) remain underexplored despite
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). While mRNA vaccines have demonstrated rapid development and high efficacy, current formulations primarily protect against severe disease rather than preventing infection at mucosal entry points
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for engineering novel antimicrobial peptides. The findings could lead to the development of new therapeutic scaffolds with applications in infectious disease, biotechnology, and immunotherapy. The project also
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for developing new treatments against drug-resistant infections. Their rapid action and ability to target bacteria in several ways make it difficult for antimicrobial resistance to emerge. Despite this promise
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enzymes. Mapping bacterial defence systems to infer predictive features of co-evolutionary dynamics. Impact and Outlook This project will: • Advance understanding of microbial co-evolution. • Deliver a
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diagnostics, empirical antibiotic use is common, exacerbating resistance. This project aims to develop a next-generation lateral flow assay (LFA) platform for rapid, ultrasensitive detection of RTI pathogens
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-pharmacological antifungal therapies. Approach and Methods: Develop and optimise laboratory models of fungal growth and resistance. Investigate how environmental stress factors (e.g. osmotic and nutrient stress
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PhD Studentship: Nanopore Technology for Rapid and Accurate Measurement of Antibiotic Concentrations
their use in field or point-of-care settings. This project aims to develop portable, nanopore-based sensors for the rapid and accurate quantification of antibiotic concentrations in environmental and clinical
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techniques. The findings will lay the groundwork for clinical application and contribute to the development of targeted therapies for resistant bacterial infections. Approach and Methods Atomic force
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plasmid efficacy against WHO-priority AMR gene analogues in relevant bacterial hosts Bioprocess optimisation: Develop high-cell-density cultivation protocols in bioreactors, addressing plasmid stability