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regions (UL-CDRs) represent a unique structural class with exceptional potential for targeting otherwise inaccessible epitopes. These UL-CDRs feature a distinctive architecture comprising a β-ribbon stalk
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rather than the structured biofilms found in real-world environments. This project investigates how engineered surface topographies influence HGT dynamics, aiming to develop design principles for materials
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: Machine Learning Molecular Dynamics. The project involves the development and application of machine learning methods that enable a major boost of the time and length scales accessible to ab-initio/first
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(SONATA, EP/V028626/1) and brings together expertise in microfluidics, fluid dynamics, nanoparticle engineering, and dental microbiology. Approach and Methods: Engineer in vitro models of bacterial biofilm
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on recent advances in recombinant RNAP production, cryo-EM structural elucidation, and fragment-based screening, the project will integrate fluorine-based NMR spectroscopy with active learning algorithms and
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treatment outcomes in vulnerable populations. Training and Student Development: The student will receive interdisciplinary training in: Peptide synthesis and structural analysis Advanced mass spectrometry
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library of polymer candidates with varied physicochemical properties (charge, size, structure, biodegradability) Formulate polymer–mRNA nanoparticles and characterise their size, stability, and mucus
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enzymes. Mapping bacterial defence systems to infer predictive features of co-evolutionary dynamics. Impact and Outlook This project will: • Advance understanding of microbial co-evolution. • Deliver a
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PhD Studentship: Nanopore Technology for Rapid and Accurate Measurement of Antibiotic Concentrations
conditions and characterise the dynamic range and sensitivity of the nanopore sensors Develop multiplexing strategies for simultaneous detection of multiple antibiotic classes Perform proof-of-principle
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chemistry and nanoscale structure, these coatings will offer long-term, biocompatible protection against infection. The project will involve materials design, fabrication, characterisation, and biological