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and a disulfide-rich knob mini-domain, enabling high stability and independent folding. Despite their promise, the structural and functional diversity of UL-CDRs remains largely unexplored. This project
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platforms, and regulatory guidance Evaluate long-term performance and potential for clinical translation Impact and Outlook: This project addresses a critical unmet need in orthopaedic surgery by developing
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: Produce recombinant viral RNAP transcription complexes in insect cells Functionally characterise RNAP activity and validate assay systems Screen fragment libraries using fluorine-based NMR spectroscopy
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that block infection at its source, with broad applicability to respiratory pathogens, including drug-resistant bacteria. Approach and Methods: Use automated synthesis platforms to generate a high-throughput
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targeting AMR gene suppression AI-driven genome design: Use LLM tools (e.g. PlasmidGPT, Evo2) to refactor plasmid genomes for enhanced manufacturability, safety, and performance Microbial validation: Test
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. This project will use large-scale metagenomic mining to uncover novel phage-host associations and identify phage-encoded enzymes, such as endolysins, with antibacterial activity. By integrating evolutionary
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diagnostics, empirical antibiotic use is common, exacerbating resistance. This project aims to develop a next-generation lateral flow assay (LFA) platform for rapid, ultrasensitive detection of RTI pathogens
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Jochen Blumberger at the Condensed Matter and Materials Physics Laboratory, University College London, UK. Interested candidates may want to work on one of the following two projects. Project 1
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PhD Studentship: Nanopore Technology for Rapid and Accurate Measurement of Antibiotic Concentrations
their use in field or point-of-care settings. This project aims to develop portable, nanopore-based sensors for the rapid and accurate quantification of antibiotic concentrations in environmental and clinical
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and quorum sensing, offering new strategies to overcome resistance. Approach and Methods: Use cross-linking mass spectrometry to identify peptide targets in mycobacterial membranes Study effects on cell