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stem/progenitor cell plasticity (HSPCs), and leukemic transformation. The project will use innovative 2D and 3D HSPC/MSC co-culture models, functional clonogenic and differentiation assays, bulk and
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cells; 2) Model AML plasticity at the single-cell level; 3) Propose candidate therapeutic targets for in vivo validation. The PhD student will be embedded in a collaborative and supportive team, working
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Malignancies: From Mechanisms to Therapies”. In this CRC we will focus on myeloid malignancies as a model to dissect the various molecular mechanisms that enable and regulate cancer cell plasticity in AML. Our
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Heidelberg University is a comprehensive university with a strong focus on research and international standards. With around 31,300 students and 8,400 employees, including numerous top researchers
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lines and cancer tissue samples. Selected candidates will be part of an international team of PhD students and postdocs that works at the forefront of biomedical research. The PhD student will be a member
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“Cellular Plasticity in Myeloid Malignancies: From Mechanisms to Therapies”. In this CRC we will focus on myeloid malignancies as a model to dissect the various molecular mechanisms that enable and regulate
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xenograft (PDX) models. To this end, the candidate will have direct access to cutting-edge mass spectrometry and advanced bioinformatics infrastructure. The project is part of the collaborative research
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Great interest in pre-clinical in vivo models Ideally initial experience with Bioinformatics experience, especially in R What we offer Goal-oriented, individual training and development opportunities
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adults, characterised by severe genomic instability and a lack of targeted therapies. Using cutting-edge methods and unique primary patient-derived cell models, this project will seek to understand
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“Cellular Plasticity in Myeloid Malignancies: From Mechanisms to Therapies”. In this CRC we will focus on myeloid malignancies as a model to dissect the various molecular mechanisms that enable and regulate