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microenvironment shapes transcriptional and genetic heterogeneity in chronic lymphocytic leukemia. Blood Advances 2022 https://pubmed.ncbi.nlm.nih.gov/35358998/ Hoferkova et al. Stromal cells engineered to express T
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), which establishes and maintains transcriptionally silent chromatin states. This PhD project aims to investigate how structural and biochemical features of these Polycomb proteins determine their
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