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, improve administration via intravenous instead of intrathecal routes, and decrease toxicity associated with ASO treatment. The candidate will be involved in both the generation and the testing of the ASO
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datasets for single nucleotide variants, structural variants, and tandem repeats relevant to FTLD Use cutting-edge bioinformatics software and methods, or develop novel tools when appropriate
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method, can engineer thousands of defined mutations in parallel in a single test tube in yeast. Strains are tagged by DNA barcodes, allowing to efficiently track mutations in cell populations during
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this specificity and test how these regulate structure and function of higher-order thalamocortical inputs in cortical circuits. The applicant will use various technologies, including super-resolution imaging