18 phd-in-computational-mechanics-"FEMTO-ST"-"FEMTO-ST" positions at UCL in United Kingdom
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disinfectants. With antimicrobial resistance (AMR) on the rise, there is an urgent need for non-antibiotic strategies to prevent and control biofilm formation on medical devices. This PhD project proposes a novel
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will uncover the interfacial solvation structure, validated through comparison between computed and experimental sum-frequency vibrational spectroscopies, as well as the mechanism of chemical
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Supervisors: Prof Manish Tiwari Prof Shervanthi Homer-Vanniasinkam Clinical Partner: The Royal National Orthopaedic Hospital (RNOH) Collaborator: Dr. Priya Mandal – UCL Mechanical Engineering
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mechanisms to guide the design and formulation of nanoparticles with superior drug delivery properties. Investigate the interaction between ultrasound, nanoparticles, and biofilms to assess antimicrobial
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the synergistic effects of monoclonal antibodies and colistin. Building on extensive preliminary data, the project aims to uncover the mechanisms behind this synergy using advanced biophysical and molecular
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such as, but not limited to, chemical, pharmaceutical, biochemical, or mechanical engineering; pharmaceutical sciences; materials science; or related areas. Applicants from computer science with relevant
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microenvironment to weaken resistance mechanisms and enhance the efficacy of existing treatments. By manipulating stress responses in fungi such as Saccharomyces cerevisiae and Aspergillus nidulans, the project aims
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with experimental virologists to validate computational predictions Impact and Outlook: This project will uncover the untapped structural and functional potential of bovine UL-CDRs, laying the groundwork
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mycobacterial infections. The student will characterise their mechanisms of action using cross-linking mass spectrometry and assess their effects on mycobacterial membrane integrity and cell wall metabolism
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for Doctoral Training in Engineering Solutions for Antimicrobial Resistance. Further details about the CDT and programme can be found at AMR CDT webiste Applications should be submitted by 12th January 2026.