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Ascl1 are important. We have undertaken a comprehensive discovery experiment to identify all the proteins that can physically interact with Ascl1, using a method we developed called RIME (Rapid
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target, since all known treatment resistance mechanisms are downstream of, and dependent on FOXA1. However, FOXA1 has been a difficult protein to study for technical reasons. We have developed a novel tool
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of our approach is the innovation of novel methods to investigate genome function. For example, we have recently developed ways to map the binding of nucleic acid-interacting drugs and small molecules
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it is possible to tune the FTU by changing the nozzle size, it may not be practical or economically feasible to expect manufacturers to develop nozzles of various sizes to enable facile dosing
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therapy (Simpson et al. in preparation*). When these local metabolic / immunologic changes happen during pancreatic cancer evolution remains unknown. More importantly, whether these spatial changes can be
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to apply early. The second quantum revolution aims to create devices that exhibit a quantum advantage – a step-change in performance gained by leveraging properties of quantum mechanics. The development
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motion and the viewing perspective of the observer (Nikolaidis et al, 2016). This project will develop continuous models of action legibility using these sources of information from data collected in a
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. Project details In this project we aim to develop graph deep learning methods that model spatial-temporal brain dynamics for accurate and interpretable detection of neurodegenerative diseases
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This PhD project offers the opportunity to explore a rich and rapidly developing area of research where powerful mathematical ideas unlock exact solutions in quantum physics. Most physical systems
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will be defined, decomposed and assessed through attention to artefacts and practices across a range of sectors and disciplines. Focusing on the automotive context, the project will develop a