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iPSC modelling Objective: Investigate molecular mechanisms underlying microglial vulnerability to cellular senescence in Multiple Sclerosis (MS), using human iPSC-derived models and advanced gene editing
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research program exploring: (i) the role of replication timing in cell-fate transitions; (ii) the impact of ERCE sequence variation on phenotypic traits; and/or (iii) the potential of ERCEs as tools for cell
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