14 structural-engineering "https:" "https:" "https:" "https:" "https:" "https:" "Multiple" "https:" positions at CEITEC MU in Czech
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literature: Sandova V et al. IL4-STAT6 signaling induces CD20 in chronic lymphocytic leukemia and this axis is repressed by PI3K delta inhibitor idelalisib. Haematologica. 2021;106(11):2995-2999. https
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microenvironmental interactions of CLL. We will decipher the molecular functions of these lncRNAs using biochemical and cellular approaches and via a novel lncRNA knock-out mouse model. We have engineered mice
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to targeted therapy. Recommended literature: Hoferkova E, et al…. Mraz M. Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations
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that induce fusion between lipid vesicles and endosomes. Using mesoscopic simulations, we will identify the key structural features of proteins with a transmembrane domain that promote membrane fusion
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Computational Quantum Chemistry & Spectroscopy About this position: Do you have a passion for understanding the electronic structure of molecules? Join our team! Our research focuses on the relationship between
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microenvironment shapes transcriptional and genetic heterogeneity in chronic lymphocytic leukemia. Blood Advances 2022 https://pubmed.ncbi.nlm.nih.gov/35358998/ Hoferkova et al. Stromal cells engineered to express T
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Research 43(5):2575-89 (2015) Bösken CA, Farnung L, Hintermair C, Merzel Schachter M, Vogel-Bachmayr K, Blazek D, Anand K, Fisher RP, Eick D, Geyer M. The structure and substrate specificity of human Cdk12
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/s41580-023-00668-x Wang L.; Wang G.; Mao W.; et al. Bioinspired engineering of fusogen and targeting moiety equipped nanovesicles. Nat Commun 2023, 14, 3366, doi: 10.1038/s41467-023-39181-2 Research area
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regulators and non-coding RNAs. Semin Oncol. 2018 Oct;45(5-6):291-30 https://pubmed.ncbi.nlm.nih.gov/30360879/ Zeni and Mraz LncRNAs in adaptive immunity: role in physiological and pathological conditions. RNA
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Axis Regulates Homing Capacity and Tonic AKT Activity in Chronic Lymphocytic Leukemia. Blood 2021 March (epub). https://pubmed.ncbi.nlm.nih.gov/33786575/ Pavlasova G, et al…. Mraz M. Ibrutinib inhibits