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processivity of RNA Polymerase IIat core DNA replication genes. Apart from the C-terminal domain of RNA Polymerase II, other cellular substrates of CDK12 are not known. In this research, we propose using a
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. Annotation: Protein-DNA interactions are critical in cellular processes and genetic instability-related conditions, particularly involving G-quadruplexes (G4) and their complementary C-rich sequences (i-Motif
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references: 1) A. Sasukimar et al. Supramolecular covalency of halogen bonds revealed by NMR contact shifts in paramagnetic cocrystals. Chem. Sci. 2025, 16, 20239-20244. https://doi.org/10.1039/D5SC05769H . 2
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literature: Beekman et al. The reference epigenome and regulatory landscape of chronic lymphocytic leukemia. Nature Medicine 2018 https://pubmed.ncbi.nlm.nih.gov/29785028/ Sun et al. The immune
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regulators and non-coding RNAs. Semin Oncol. 2018 Oct;45(5-6):291-30 https://pubmed.ncbi.nlm.nih.gov/30360879/ Zeni and Mraz LncRNAs in adaptive immunity: role in physiological and pathological conditions. RNA
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Axis Regulates Homing Capacity and Tonic AKT Activity in Chronic Lymphocytic Leukemia. Blood 2021 March (epub). https://pubmed.ncbi.nlm.nih.gov/33786575/ Pavlasova G, et al…. Mraz M. Ibrutinib inhibits
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-Guest Complementarity in Supramolecular Monofunctional Platinum(II) Drugs. Inorganic Chemistry Frontiers, 2024, 11, 8510-8525. https://doi.org/10.1039/D4QI02012J . Ideal candidate profile: Must-have
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-in-3d-stem-cell-derived-human-organ-models/t11589 Where to apply Website https://www.ceitec.eu/protein-in-cell-nmr-spectroscopy-in-3d-stem-cell-derived-… Requirements LanguagesENGLISHLevelGood
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research assistants for several years. Start date: September/ October 2026 Sign-up link: Where to apply Website http://Miloslava.Kollarcikova@ceitec.muni.cz Requirements Additional Information Work Location